Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children
- Jung, Kyung Hwa
- Torrone, David Z.
- Lovinsky-Desir, Stephanie
- Perzanowski, Matthew S.
- Bautista, Joshua B.
- Jezioro, Jacqueline R.
- Hoepner, Lori A.
- Ross, Jamie
- Perera, Frederica P.
- Chillrud, Steven N.
- Miller, Rachel L.
DOIAbstract
BACKGROUND: Both short and long-term exposure to traffic-related air pollutants have been associated with asthma and reduced lung function. We hypothesized that short-term indoor exposure to fine particulate matter <2.5 μm (PM2.5) and vanadium (V) would be associated with altered buccal cell DNA methylation of targeted asthma genes and decreased lung function among urban children in a nested subcohort of African American and Dominican children. METHODS: Six day integrated levels of air pollutants were measured from children's homes (age 9-14; n = 163), repeated 6 months later (n = 98). Buccal samples were collected repeatedly during visits. CpG promoter loci of asthma genes (i.e., interleukin 4 (IL4), interferon gamma (IFNγ), inducible nitr...
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