Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci
- Tragante, Vinicius
- Barnes, Michael R.
- Ganesh, Santhi K.
- Lanktree, Matthew B.
- Guo, Wei
- Franceschini, Nora
- Smith, Erin N.
- Johnson, Toby
- Holmes, Michael V.
- Padmanabhan, Sandosh
- Karczewski, Konrad J.
- Almoguera, Berta
- Barnard, John
- Baumert, Jens
- Chang, Yen-Pei Christy
- Elbers, Clara C.
- Farrall, Martin
- Fischer, Mary E.
- Gaunt, Tom R.
- Gho, Johannes M. I. H.
- Gieger, Christian
- Goel, Anuj
- Gong, Yan
- Isaacs, Aaron
- Kleber, Marcus E.
- Leach, Irene Mateo
- McDonough, Caitrin W.
- Meijs, Matthijs F. L.
- Melander, Olle
- Nelson, Christopher P.
- Nolte, Ilja M.
- Pankratz, Nathan
- Price, Tom S.
- Shaffer, Jonathan
- Shah, Sonia
- Tomaszewski, Maciej
- van der Most, Peter J.
- Van Iperen, Erik P. A.
- Vonk, Judith M.
- Witkowska, Kate
- Wong, Caroline O. L.
- Zhang, Li
- Beitelshees, Amber L.
- Berenson, Gerald S.
- Bhatt, Deepak L.
- Brown, Morris
- Burt, Amber
- Cooper-DeHoff, Rhonda M.
- Connell, John M.
- Cruickshanks, Karen J.
- Curtis, Sean P.
- Davey-Smith, George
- Delles, Christian
- Gansevoort, Ron T.
- Guo, Xiuqing
- Haiqing, Shen
- Hastie, Claire E.
- Hofker, Marten H.
- Hovingh, G. Kees
- Kim, Daniel S.
- Kirkland, Susan A.
- Klein, Barbara E.
- Klein, Ronald
- Li, Yun R.
- Maiwald, Steffi
- Newton-Cheh, Christopher
- O’Brien, Eoin T.
- Onland-Moret, N. Charlotte
- Palmas, Walter R.
- Parsa, Afshin
- Penninx, Brenda W.
- Pettinger, Mary
- Vasan, Ramachandran S.
- Ranchalis, Jane E.
- Ridker, Paul M.
- Rose, Lynda M.
- Sever, Peter
- Shimbo, Daichi
- Steele, Laura
- Stolk, Ronald P.
- Thorand, Barbara
- Trip, Mieke D.
- van Duijn, Cornelia M.
- Verschuren, W. Monique
- Wijmenga, Cisca
- Wyatt, Sharon
- Young, J. Hunter
- Zwinderman, Aeilko H.
- Bezzina, Connie R.
- Boerwinkle, Eric
- Casas, Juan P.
- Caulfield, Mark J.
- Chakravarti, Aravinda
- Chasman, Daniel I.
- Davidson, Karina W.
- Doevendans, Pieter A.
- Dominiczak, Anna F.
- FitzGerald, Garret A.
- Gums, John G.
- Fornage, Myriam
- Hakonarson, Hakon
- Halder, Indrani
- Hillege, Hans L.
- Illig, Thomas
- Jarvik, Gail P.
- Johnson, Julie A.
- Kastelein, John J. P.
- Koenig, Wolfgang
- Kumari, Meena
- Marz, Winfried
- Murray, Sarah S.
- O’Connell, Jeffrey R.
- Oldehinkel, Albertine J.
- Pankow, James S.
- Rader, Daniel J.
- Redline, Susan
- Reilly, Muredach P.
- Schadt, Eric E.
- Kottke-Marchant, Kandice
- Snieder, Harold
- Snyder, Michael
- Stanton, Alice V.
- Tobin, Martin D.
- Uitterlinden, Andre G.
- van der Harst, Pim
- van der Schouw, Yvonne T.
- Samani, Nilesh J.
- Watkins, Hugh
- Johnson, Andrew D.
- Reiner, Alex P.
- Zhu, Xiaofeng
- de Bakker, Paul I. W.
- Levy, Daniel
- Asselbergs, Folkert W.
- Munroe, Patricia B.
- Keating, Brendan J.
DOIAbstract
Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p < 6 × 10−7) and confirmed 27 previously reported associations. Bioinformat...
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