Adherence with tobramycin inhaled solution and health care utilization

Fouayzi, Hassan
Quittell, Lynne M.
Sacco, Patricia
Briesacher, Becky
Quittner, Alexandra
Saiman, Lisa

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Publication date

January 2011

DOI

10.7916/D82Z13X1

Publisher

Columbia University Libraries/Information Services

Abstract

Adherence with tobramycin inhalation solution (TIS) during routine cystic fibrosis (CF) care may differ from recommended guidelines and affect health care utilization. We analyzed 2001-2006 healthcare claims data from 45 large employers. Study subjects had diagnoses of CF and at least 1 prescription for TIS. We measured adherence as the number of TIS therapy cycles completed during the year and categorized overall adherence as: low ≤ 2 cycles, medium >2 to <4 cycles, and high ≥ 4 cycles per year. Interquartile ranges (IQR) were created for health care utilization and logistic regression analysis of hospitalization risk was conducted by TIS adherence categories. Among 804 individuals identified with CF and a prescription for TIS, only 7% (n ...