The generation of functional neural circuitries requires neuronal migration, a central component of proper nervous system development. When defective, it can lead to devastating conditions including epilepsy and mental retardation. In the nematode C. elegans, neurons undergo both short- and long-range migrations that are regulated by conserved pathways. In my thesis study, I explore novel roles for both the insulin/IGF-1 signaling pathway and RNAi factors in neuronal migration by using the embryonic anterior migrations of the hermaphrodite-specific neurons (HSNs) of C. elegans as a model. I demonstrate that the insulin/IGF-1 signaling pathway modulates the activity of the conserved DAF-16/FOXO transcription factor non-autonomously in the hy...
abstract: Proper cell growth and differentiation requires the integration of multiple signaling path...
Neuronal apoptosis is an essential process occurring not only during normal development but also in ...
Cellular differentiation is the cornerstone of metazoan development. Cell-cell signaling mechanisms ...
MIG-10 is a C.elegans protein known to stimulate lamellipodia formation in directed neuronal migrati...
How individual neurons in a nervous system give rise to complex function, behavior and consciousness...
As embryos proceed through development, they must undergo a series of cell fate decisions. At each ...
The Rbfox proteins are a family of splicing regulators in post-mitotic neurons, predicted to be requ...
MYCN amplification is a genetic hallmark of the childhood tumour neuroblastoma. MYCN-MAX dimers acti...
PhD ThesisNeuroblastoma is a cancer of the sympathetic nervous system derived from neural crest cell...
MIG-10 is involved in the signal transduction of guidance cues during neuronal migration and has sho...
The nervous system is the most complex and diverse system of the human body. And so it is in the rou...
The architecture of neocortical projection neurons is subject of a complex gene control. Here we dem...
Neuronal migration is an essential aspect of nervous system development; improper or incomplete neur...
Foxg1 is an evolutionary conserved transcription factor gene playing a crucial role in a variety of...
Stem cells are defined by their capacity to differentiate into different phenotypes while maintainin...
abstract: Proper cell growth and differentiation requires the integration of multiple signaling path...
Neuronal apoptosis is an essential process occurring not only during normal development but also in ...
Cellular differentiation is the cornerstone of metazoan development. Cell-cell signaling mechanisms ...
MIG-10 is a C.elegans protein known to stimulate lamellipodia formation in directed neuronal migrati...
How individual neurons in a nervous system give rise to complex function, behavior and consciousness...
As embryos proceed through development, they must undergo a series of cell fate decisions. At each ...
The Rbfox proteins are a family of splicing regulators in post-mitotic neurons, predicted to be requ...
MYCN amplification is a genetic hallmark of the childhood tumour neuroblastoma. MYCN-MAX dimers acti...
PhD ThesisNeuroblastoma is a cancer of the sympathetic nervous system derived from neural crest cell...
MIG-10 is involved in the signal transduction of guidance cues during neuronal migration and has sho...
The nervous system is the most complex and diverse system of the human body. And so it is in the rou...
The architecture of neocortical projection neurons is subject of a complex gene control. Here we dem...
Neuronal migration is an essential aspect of nervous system development; improper or incomplete neur...
Foxg1 is an evolutionary conserved transcription factor gene playing a crucial role in a variety of...
Stem cells are defined by their capacity to differentiate into different phenotypes while maintainin...
abstract: Proper cell growth and differentiation requires the integration of multiple signaling path...
Neuronal apoptosis is an essential process occurring not only during normal development but also in ...
Cellular differentiation is the cornerstone of metazoan development. Cell-cell signaling mechanisms ...