Genetic disorders of transporters/channels in the inner ear and their relation to the kidney.
- Peters, T.A.
- Monnens, L.A.H.
- Cremers, C.W.R.J.
- Curfs, J.H.A.J.
Publication date
January 2004
DOI Publisher
Springer Science and Business Media LLC ISSN
0931-041X Citation count (estimate)
17Abstract
Contains fulltext : 58356.pdf (publisher's version ) (Closed access)Inner ear physiology is reviewed with emphasis on features common to renal physiology. Genetic disorders in transporters/channels for chloride (ClC-K), bicarbonate (Cl(-)/HCO(3)(-) exchanger), protons (H(+)-ATPase), sodium (ENaC, NKKC1, NBC3, NHE3), potassium (KCNQ1/KCNE1, Kcc4), and water (AQP4) in the inner ear and their relation to the kidney are discussed. Based on data from human disorders (with or without mouse counterparts) and mouse models (without human counterparts) this article focuses on the involvement of these transporters/channels in hearing loss
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