Dendritic spines receive most synaptic inputs in the forebrain. Their morphology, with a spine head isolated from the dendrite by a slender neck, indicates a potential role in isolating inputs. Indeed, biochemical compartmentalization occurs at spine heads because of the diffusional bottleneck created by the spine neck. Here we investigate whether the spine neck also isolates inputs electrically. Using two-photon uncaging of glutamate on spine heads from mouse layer-5 neocortical pyramidal cells, we find that the amplitude of uncaging potentials at the soma is inversely proportional to neck length. This effect is strong and independent of the position of the spine in the dendritic tree and size of the spine head. Moreover, spines with long ...
The electrical properties of a cortical (spiny) pyramidal cell were analysed on the basis of passive...
NMDA receptors mediate increases in the intracellular free Ca2+ concentration ([Ca2+]i) of neurons ...
One of the biggest remaining mysteries of science is inside our heads: how does nature wire up a hig...
In mammalian cortex, most excitatory inputs occur on dendritic spines, avoiding dendritic shafts. Al...
Dendritic spines receive the majority of excitatory inputs in many mammalian neurons, but their biop...
Dendritic spines mediate most excitatory inputs in the brain. Although it is clear that spines compa...
Dendritic spines are micron-sized protrusions that harbor the majority of excitatory synapses in the...
Excitatory postsynaptic potentials (EPSPs) occur when the neurotransmitter glutamate binds to postsy...
Dendritic spines have been proposed to transform synaptic signals through chemical and electrical co...
Dendritic spines are the main receptacles of excitatory information in the brain. Their particular m...
Excitatory input onto many neurons in the brain occurs onto specialized projections called dendritic...
Many neurons receive excitatory glutamatergic input almost exclusively onto dendritic spines. In the...
Dendritic spines are tiny protrusions on dendritic shafts where most excitatory synapses are located...
SummaryThe roles of voltage-sensitive sodium (Na) and calcium (Ca) channels located on dendrites and...
Dendritic spines mediate most excitatory synapses in the brain. Past theoretical work and recent exp...
The electrical properties of a cortical (spiny) pyramidal cell were analysed on the basis of passive...
NMDA receptors mediate increases in the intracellular free Ca2+ concentration ([Ca2+]i) of neurons ...
One of the biggest remaining mysteries of science is inside our heads: how does nature wire up a hig...
In mammalian cortex, most excitatory inputs occur on dendritic spines, avoiding dendritic shafts. Al...
Dendritic spines receive the majority of excitatory inputs in many mammalian neurons, but their biop...
Dendritic spines mediate most excitatory inputs in the brain. Although it is clear that spines compa...
Dendritic spines are micron-sized protrusions that harbor the majority of excitatory synapses in the...
Excitatory postsynaptic potentials (EPSPs) occur when the neurotransmitter glutamate binds to postsy...
Dendritic spines have been proposed to transform synaptic signals through chemical and electrical co...
Dendritic spines are the main receptacles of excitatory information in the brain. Their particular m...
Excitatory input onto many neurons in the brain occurs onto specialized projections called dendritic...
Many neurons receive excitatory glutamatergic input almost exclusively onto dendritic spines. In the...
Dendritic spines are tiny protrusions on dendritic shafts where most excitatory synapses are located...
SummaryThe roles of voltage-sensitive sodium (Na) and calcium (Ca) channels located on dendrites and...
Dendritic spines mediate most excitatory synapses in the brain. Past theoretical work and recent exp...
The electrical properties of a cortical (spiny) pyramidal cell were analysed on the basis of passive...
NMDA receptors mediate increases in the intracellular free Ca2+ concentration ([Ca2+]i) of neurons ...
One of the biggest remaining mysteries of science is inside our heads: how does nature wire up a hig...