Retinoic acid (RA)-signaling is involved in a broad spectrum of cellular processes, including formation of most embryonic tissues, epithelial differentiation, and is a critical regulator of stem cell differentiation in vitro. Studies from our lab have focused on the role of RA-signaling in the urinary tract, where we find that it plays multiple roles. By inducing expression of a floxed dominant-negative mutant Rar receptor, termed RaraDN, in the bladder, we find that RA-receptor signaling from the bladder epithelium plays distinct roles during urinary tract development; it is required for establishing mature ureter-bladder connections and for differentiation of the bladder epithelia. Congenital abnormalities of the kidney and urinary tract ...
Retinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney ...
Individuals born with low renal reserves are predisposed to progressive renal disease and primary h...
The urinary bladder and associated tract are lined by the urothelium, a transitional epithelium that...
The bladder urothelium is a stratified epithelium that interconnects with the ureters to form the ur...
SummaryThe urothelium is a multilayered epithelium that serves as a barrier between the urinary trac...
retinoic acid (tRA), which binds retinoic acid receptors (RARs) to modulate gene expression. We and...
The urinary bladder and associated tract are lined by the urothelium, a transitional epithelium that...
RET is a tyrosine kinase receptor that induces cell survival, proliferation and migration. When bou...
Vitamin A is necessary for kidney development and has also been linked to regulation of solute and w...
The interactions between the nephrogenic mesenchyme and the ureteric bud during kidney development a...
The interactions between the nephrogenic mesenchyme and the ureteric bud during kidney development a...
Retinoic acid (RA) signaling is a crucial developmental pathway involved in urothelium development, ...
The mechanisms by which a subset of mesodermal cells are committed to a nephrogenic fate are largely...
The interactions between the nephrogenic mesenchyme and the ureteric bud during kidney development a...
AbstractThe mechanisms by which a subset of mesodermal cells are committed to a nephrogenic fate are...
Retinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney ...
Individuals born with low renal reserves are predisposed to progressive renal disease and primary h...
The urinary bladder and associated tract are lined by the urothelium, a transitional epithelium that...
The bladder urothelium is a stratified epithelium that interconnects with the ureters to form the ur...
SummaryThe urothelium is a multilayered epithelium that serves as a barrier between the urinary trac...
retinoic acid (tRA), which binds retinoic acid receptors (RARs) to modulate gene expression. We and...
The urinary bladder and associated tract are lined by the urothelium, a transitional epithelium that...
RET is a tyrosine kinase receptor that induces cell survival, proliferation and migration. When bou...
Vitamin A is necessary for kidney development and has also been linked to regulation of solute and w...
The interactions between the nephrogenic mesenchyme and the ureteric bud during kidney development a...
The interactions between the nephrogenic mesenchyme and the ureteric bud during kidney development a...
Retinoic acid (RA) signaling is a crucial developmental pathway involved in urothelium development, ...
The mechanisms by which a subset of mesodermal cells are committed to a nephrogenic fate are largely...
The interactions between the nephrogenic mesenchyme and the ureteric bud during kidney development a...
AbstractThe mechanisms by which a subset of mesodermal cells are committed to a nephrogenic fate are...
Retinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney ...
Individuals born with low renal reserves are predisposed to progressive renal disease and primary h...
The urinary bladder and associated tract are lined by the urothelium, a transitional epithelium that...