Fasciola hepatica infection continues to be a major problem in the agriculture sector, particularly in sheep and cattle. Cathepsin L and B proteases are major components of the excretory/secretory material of the parasite, and their roles in several important aspects of parasite invasion and survival has led to their use as targets in rational vaccine design. Previous studies in rats demonstrated that the use of stage-specific antigens, cathepsin B2 and cathepsin L5, as part of a multivalent vaccine, was able to confer significant protection against challenge. In the present study, recombinant versions of cathepsin L5 and cathepsin B2 produced in yeast were used in combination to vaccinate sheep. Intramuscular and intranasal forms of admini...
Fasciolosis, caused by the liver flukes Fasciola hepatica and F. gigantica, is an economically impor...
Mice were vaccinated with recombinant Schistosoma japonicum cathepsin D aspartic protease, expressed...
Schistosomiasis is caused by several worm species of the genus Schistosoma and afflicts up to 600 mi...
Liver flukes produce cathepsin B and cathepsin L in their excretory-secretory material. These protea...
AbstractFasciola's excretory-secretory material comprises chiefly cathepsin B and cathepsin L. These...
Fasciola's excretory-secretory material comprises chiefly cathepsin B and cathepsin L. These cystein...
The liver fluke, Fasciola hepatica causes liver fluke disease, or fasciolosis, in ruminants such as ...
Fasciola hepatica secretes cathepsin L proteases that facilitate the penetration of the parasite thr...
Fasciola hepatica secretes cathepsin L proteases that facilitate the penetration of the parasite thr...
Fasciola hepatica infection causes important economic losses in livestock and food industries around...
Background Cysteine proteinases of Fasciola hepatica are important candidates for vaccine antigens b...
The liver fluke Fasciola hepatica is an economically important global pathogen of humans and their l...
Fasciola hepatica juveniles express immunodominant cathepsin L proteins, which are mainly found in t...
Cathepsin L (CL)-like proteases are important candidate vaccine antigens for protection against helm...
The liver flukes Fasciola hepatica and F. gigantica cause infectious disease in ruminants and humans...
Fasciolosis, caused by the liver flukes Fasciola hepatica and F. gigantica, is an economically impor...
Mice were vaccinated with recombinant Schistosoma japonicum cathepsin D aspartic protease, expressed...
Schistosomiasis is caused by several worm species of the genus Schistosoma and afflicts up to 600 mi...
Liver flukes produce cathepsin B and cathepsin L in their excretory-secretory material. These protea...
AbstractFasciola's excretory-secretory material comprises chiefly cathepsin B and cathepsin L. These...
Fasciola's excretory-secretory material comprises chiefly cathepsin B and cathepsin L. These cystein...
The liver fluke, Fasciola hepatica causes liver fluke disease, or fasciolosis, in ruminants such as ...
Fasciola hepatica secretes cathepsin L proteases that facilitate the penetration of the parasite thr...
Fasciola hepatica secretes cathepsin L proteases that facilitate the penetration of the parasite thr...
Fasciola hepatica infection causes important economic losses in livestock and food industries around...
Background Cysteine proteinases of Fasciola hepatica are important candidates for vaccine antigens b...
The liver fluke Fasciola hepatica is an economically important global pathogen of humans and their l...
Fasciola hepatica juveniles express immunodominant cathepsin L proteins, which are mainly found in t...
Cathepsin L (CL)-like proteases are important candidate vaccine antigens for protection against helm...
The liver flukes Fasciola hepatica and F. gigantica cause infectious disease in ruminants and humans...
Fasciolosis, caused by the liver flukes Fasciola hepatica and F. gigantica, is an economically impor...
Mice were vaccinated with recombinant Schistosoma japonicum cathepsin D aspartic protease, expressed...
Schistosomiasis is caused by several worm species of the genus Schistosoma and afflicts up to 600 mi...