In agriculture, weather is the main factor of variability between two consecutive years. This thesis aims to build large-scale statistical models that estimate the impact of weather conditions on agricultural yields. The scarcity of available agricultural data makes it necessary to construct simple models with few predictors, and to adapt model selection methods to avoid overfitting. Careful validation of statistical models is a major concern of this thesis. Neural networks and mixed effects models are compared, showing the importance of local specificities. Estimates of US corn yield at the end of the year show that temperature and precipitation information account for an average of 28% of yield variability. In several more weather-sensiti...