Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
- Gudmundsson, J.
- Sulem, P.
- Steinthorsdottir, V.
- Bergthorsson, J.T.
- Thorleifsson, G.
- Manolescu, A.
- Rafnar, T.
- Gudbjartsson, D.F.
- Agnarsson, B.A.
- Baker, A.
- Sigurdsson, A.
- Benediktsdottir, K.R.
- Jakobsdottir, M.
- Blondal, T.
- Stacey, S.N.
- Helgason, A.
- Gunnarsdottir, S.
- Olafsdottir, A.
- Kristinsson, K.T.
- Birgisdottir, B.
- Ghosh, S.
- Thorlacius, S.
- Magnusdottir, D.
- Stefansdottir, G.
- Kristjansson, K.
- Bagger, Y.
- Wilensky, R.L.
- Reilly, M.P.
- Morris, A.D.
- Kimber, C.H.
- Adeyemo, A.
- Chen, Y.
- Zhou, J.
- So, W.Y.
- Tong, P.C.
- Ng, M.C.
- Hansen, T.
- Andersen, G.
- Borch-Johnsen, K.
- Jorgensen, T.
- Tres, A.
- Fuertes, F.
- Ruiz-Echarri, M.
- Asin, L.
- Saez, B.
- Boven, E. van
- Klaver, S.
- Swinkels, D.W.
- Aben, K.K.H.
- Graif, T.
- Cashy, J.
- Suarez, B.K.
- Vierssen Trip, O. van
- Frigge, M.L.
- Ober, C.
- Hofker, M.H.
- Wijmenga, C.
- Christiansen, C.
- Rader, D.J.
- Palmer, C.N.
- Rotimi, C.
- Chan, J.C.
- Pedersen, O.
- Sigurdsson, G.
- Benediktsson, R.
- Jonsson, E.
- Einarsson, G.V.
- Mayordomo, J.I.
- Catalona, W.J.
- Kiemeney, L.A.L.M.
- Barkardottir, R.B.
- Gulcher, J.R.
- Thorsteinsdottir, U.
- Kong, A.
- Stefansson, K.
DOIAbstract
Contains fulltext : 52115.pdf (publisher's version ) (Closed access)We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2...
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