Effect of age and radiation dose on local control after breast conserving treatment: EORTC trial 22881-10882.
- Antonini, N.
- Jones, H.
- Horiot, J.C.
- Poortmans, P.M.P.
- Struikmans, H.
- Bogaert, W. van den
- Barillot, I.
- Fourquet, A.
- Jager, J.
- Hoogenraad, W.J.
- Collette, L.
- Pierart, M.
- Hart, G.
- Bartelink, H.
DOIAbstract
Contains fulltext : 51878.pdf (publisher's version ) (Closed access)PURPOSE: To determine whether the effect of an additional "boost" radiation after breast conservative therapy (BCT) on local control depends on age and evaluate the impact of a treatment policy with a threshold for age. PATIENTS AND METHODS: We used data from EORTC 22881-10882 trial, with median follow-up of 77.4 months. Patients receiving BCT and 50Gy whole breast irradiation were randomized to no boost and 16Gy boost (N=5318). RESULTS: In univariate analysis, a boost reduced local failure by a factor of 2 (P<0.0001). Multivariate analysis showed local control increased with age (P=0.0003). There was no evidence that the relative effect of a boost on loca...
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