Interleukin-18 does not modulate the acute-phase response.
- Stuyt, R.J.L.
- Netea, M.G.
- Verschueren, C.M.M.
- Dinarello, C.A.
- Kullberg, B.J.
- Meer, J.W.M. van der
Publication date
January 2005
DOI Publisher
SAGE Publications ISSN
0968-0519 Citation count (estimate)
14Abstract
Contains fulltext : 47490.pdf (publisher's version ) (Open Access)IL-18 is a pro-inflammatory cytokine of the IL-1 family and it induces IL-1, TNF, and IL-6, all of which are endogenous pyrogens. The pyrogenic properties of recombinant IL-18 were studied in a rabbit model of fever. rIL-18 did not cause fever when injected intravenously into rabbits. Furthermore, the ability of rIL-18 to modulate other components of the acute-phase response was assessed. rIL-18 did not induce leukocytosis, or changes of circulating concentrations of lipoproteins and corticosterone in mice. In conclusion, rIL-18 is not able to induce a febrile response in rabbits and does not modulate the acute-phase response in mice
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