Introduction Fibroblast differentiation in myofibroblasts is a key feature of idiopathic pulmonary fibrosis (IPF). Recent evidence points to Paired-related homeobox (PRRX) transcription factors (TF) as regulating mesenchymal cell fate during development and as a key TF at the center of a network coordinating fibroblast differentiation. We hypothesized that PRRX1 modulates fibroblast phenotype in IPF and is involved in lung fibrosis development. Material and methods Immunohistochemistry (IHC) and real-time quantitative PCR for PRRX were performed on human lung samples and primary human lung fibroblasts (HLF) cultured from IPF and controls. PRRX1 overexpression was obtained in HLF with plasmid transfection. Functional experiments were perform...
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an appalling prognos...
Tissue remodeling of sub-epithelial mesenchymal cells is a major pathology occurring in chronic obst...
INTRODUCTION: Fibroblastic foci represent the cardinal pathogenic lesion in idiopathic pulmonary fib...
Introduction Fibroblast differentiation in myofibroblasts is a key feature of idiopathic pulmonary f...
Matrix remodeling is a salient feature of idiopathic pulmonary fibrosis (IPF) and cells of mesenchym...
La Fibrose Pulmonaire Idiopathique (FPI), est une maladie pulmonaire chronique, sans aucune thérapeu...
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with limited therapeutic options and unk...
Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic lung disease with a media...
Idiopathic pulmonary fibrosis (IPF), a chronic progressive interstitial pneumonia, is characterized ...
AbstractObjectiveIdiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by epith...
Heritable profibrotic differentiation of lung fibroblasts is a key mechanism of idiopathic pulmonary...
Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease, marked by excessive scarr...
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. During the...
Abstract Background Neurotrophins (NT) belongs to a family of growth factors which promotes neurons ...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease with very few effective treatme...
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an appalling prognos...
Tissue remodeling of sub-epithelial mesenchymal cells is a major pathology occurring in chronic obst...
INTRODUCTION: Fibroblastic foci represent the cardinal pathogenic lesion in idiopathic pulmonary fib...
Introduction Fibroblast differentiation in myofibroblasts is a key feature of idiopathic pulmonary f...
Matrix remodeling is a salient feature of idiopathic pulmonary fibrosis (IPF) and cells of mesenchym...
La Fibrose Pulmonaire Idiopathique (FPI), est une maladie pulmonaire chronique, sans aucune thérapeu...
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with limited therapeutic options and unk...
Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic lung disease with a media...
Idiopathic pulmonary fibrosis (IPF), a chronic progressive interstitial pneumonia, is characterized ...
AbstractObjectiveIdiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by epith...
Heritable profibrotic differentiation of lung fibroblasts is a key mechanism of idiopathic pulmonary...
Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease, marked by excessive scarr...
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. During the...
Abstract Background Neurotrophins (NT) belongs to a family of growth factors which promotes neurons ...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease with very few effective treatme...
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an appalling prognos...
Tissue remodeling of sub-epithelial mesenchymal cells is a major pathology occurring in chronic obst...
INTRODUCTION: Fibroblastic foci represent the cardinal pathogenic lesion in idiopathic pulmonary fib...