The PEGylation of antibody fragments has been shown to greatly prolong their residence time in the lungs in mice. The purpose of this research was to confirm the effect of PEGylation in higher animal species, that is, the rat and the rabbit. An anti-IL-17A Fab' antibody fragment was conjugated to a two-armed 40kDa polyethylene glycol (PEG) via site-selective thiol PEGylation. PEGylation did not significantly alter the binding activity of the Fab' fragment but it largely enhanced its inhibitory potency. PEGylation increased the residence time of the Fab' in the lungs of mice, rats and rabbits. Following intratracheal administration, the unconjugated Fab' was cleared from the lungs within 24h while large quantities of the PEGylated Fab' remai...
Antimicrobial peptides (AMPs) have therapeutic potential, particularly for localized infections such...
Antimicrobial peptides (AMPs) have therapeutic potential, particularly for localized infections such...
Dimerized translationally controlled tumor protein (dTCTP) initiates a variety of allergic responses...
Pulmonary administration of anti-cytokine antibodies offers a targeted therapy in asthma. However, t...
In the field of therapeutic proteins, monoclonal antibodies (mAbs) are gaining momentum as an import...
PEGylation is a promising approach to increase the residence time of antibody fragments in the lungs...
More and more therapeutic proteins are developed for an administration by inhalation to treat respir...
peer reviewedPEGylation is a promising approach to increase the residence time of antibody fragments...
The aim of this study was to maximize the yield of the production of mono-PEGylated anti-interleukin...
The utility of inhaled protein therapeutics to treat lung-resident diseases is limited by protein de...
PEGylation is an attractive strategy to enhance the therapeutic efficacy of proteins with a short se...
Conjugation of recombinant human deoxyribonuclease I (rhDNase) to polyethylene glycol (PEG) of 20 to...
Conjugation of recombinant human deoxyribonuclease I (rhDNase) to large (≥ 20 kDa) polyethylene glyc...
Conjugation to high molecular weight (MW >= 20 kDa) polyethylene glycol (PEG) was previously shown t...
Conjugation to high molecular weight (MW) polyethylene glycol (PEG) was previously shown to largely ...
Antimicrobial peptides (AMPs) have therapeutic potential, particularly for localized infections such...
Antimicrobial peptides (AMPs) have therapeutic potential, particularly for localized infections such...
Dimerized translationally controlled tumor protein (dTCTP) initiates a variety of allergic responses...
Pulmonary administration of anti-cytokine antibodies offers a targeted therapy in asthma. However, t...
In the field of therapeutic proteins, monoclonal antibodies (mAbs) are gaining momentum as an import...
PEGylation is a promising approach to increase the residence time of antibody fragments in the lungs...
More and more therapeutic proteins are developed for an administration by inhalation to treat respir...
peer reviewedPEGylation is a promising approach to increase the residence time of antibody fragments...
The aim of this study was to maximize the yield of the production of mono-PEGylated anti-interleukin...
The utility of inhaled protein therapeutics to treat lung-resident diseases is limited by protein de...
PEGylation is an attractive strategy to enhance the therapeutic efficacy of proteins with a short se...
Conjugation of recombinant human deoxyribonuclease I (rhDNase) to polyethylene glycol (PEG) of 20 to...
Conjugation of recombinant human deoxyribonuclease I (rhDNase) to large (≥ 20 kDa) polyethylene glyc...
Conjugation to high molecular weight (MW >= 20 kDa) polyethylene glycol (PEG) was previously shown t...
Conjugation to high molecular weight (MW) polyethylene glycol (PEG) was previously shown to largely ...
Antimicrobial peptides (AMPs) have therapeutic potential, particularly for localized infections such...
Antimicrobial peptides (AMPs) have therapeutic potential, particularly for localized infections such...
Dimerized translationally controlled tumor protein (dTCTP) initiates a variety of allergic responses...