Stromal inflammation, necrosis and HER2 overexpression in ductal carcinoma in situ of the breast: another causality dilemma?

We read with interest the manuscript of Pruneri et al. [1] concerning tumor-infiltrating lymphocytes (TILs) in ductal carcinoma in situ (DCIS). TILs were retrospectively studied in an extensive cohort of 1488 patients. DCIS studies are often underpowered due to limited patient numbers, and robust statistical analysis is frequently hampered by low recurrence rates. Therefore, Pruneri et al. [1] provide truly valuable information for the scientific and oncologic community. However, we do have some remarks regarding the conclusions of this study. [...