OBJECTIVES : Recently, daratumumab has been included in the therapeutic strategies for myeloma patients. This molecule is an antibody directed against CD38, strongly expressed on plasma cells. Nevertheless, as CD38 is also present on erythrocyte membrane, daratumumab interferes with immunohaematological tests, complicating the selection of compatible blood. METHODS : A total of 14 patients treated by daratumumab have been followed in our transfusion laboratory. Among them, 11 have been transfused. Dithiotreitol (DTT) has been used to inhibit the daratumumab's interference, in the pre-transfusion tests (irregular antibody screening and cross-match). RESULTS : The red blood cell treatment with DTT has been very efficacious to inhibit the dara...
The use of proteasome inhibitors and immunomodulatory drugs in the clinical practice has contributed...
The efficacy of daratumumab depends partially on CD38 expression on multiple myeloma (MM) cells. We ...
Abstract Daratumumab is a human monoclonal antibody that targets CD38, a cell surface protein that i...
Introduction: Pre-transfusion tests, essential for the release of blood components, may be affected ...
Introduktion: Daratumumab är en monoklonal antikropp som används för att behandla patienter med mult...
Daratumumab has proven to be highly efficacious for relapsed and refractory multiple myeloma (MM) an...
Daratumumab är en antikropp som används vid behandling av multipelt myelom. Daratumumab är specifik ...
In recent years, the anti-CD38 monoclonal antibody daratumumab (Darzalex; Janssen-Cilag Pty Ltd) has...
none20siMonoclonal antibodies (mAbs) are a recent addition to multiple myeloma (MM) therapies and a ...
Cian McEllistrim,1 Janusz Krawczyk,1 Michael E O’Dwyer1,2 1Department of Hematology, Universit...
Multiple myeloma is a clonal disorder of plasma cells that is currently considered incurable. CD38 i...
BackgroundThe monoclonal antibody daratumumab, approved for treating myeloma, targets CD38, a protei...
Daratumumab (DARA), a monoclonal anti-CD38 antibody, belongs to the new generation of immunotherapy ...
International audienceBackground: Daratumumab (Dara), an anti-CD38 monoclonal antibody, has an immun...
Purpose: Daratumumab treatment results in a marked reduction of CD38 expression on multiple myeloma ...
The use of proteasome inhibitors and immunomodulatory drugs in the clinical practice has contributed...
The efficacy of daratumumab depends partially on CD38 expression on multiple myeloma (MM) cells. We ...
Abstract Daratumumab is a human monoclonal antibody that targets CD38, a cell surface protein that i...
Introduction: Pre-transfusion tests, essential for the release of blood components, may be affected ...
Introduktion: Daratumumab är en monoklonal antikropp som används för att behandla patienter med mult...
Daratumumab has proven to be highly efficacious for relapsed and refractory multiple myeloma (MM) an...
Daratumumab är en antikropp som används vid behandling av multipelt myelom. Daratumumab är specifik ...
In recent years, the anti-CD38 monoclonal antibody daratumumab (Darzalex; Janssen-Cilag Pty Ltd) has...
none20siMonoclonal antibodies (mAbs) are a recent addition to multiple myeloma (MM) therapies and a ...
Cian McEllistrim,1 Janusz Krawczyk,1 Michael E O’Dwyer1,2 1Department of Hematology, Universit...
Multiple myeloma is a clonal disorder of plasma cells that is currently considered incurable. CD38 i...
BackgroundThe monoclonal antibody daratumumab, approved for treating myeloma, targets CD38, a protei...
Daratumumab (DARA), a monoclonal anti-CD38 antibody, belongs to the new generation of immunotherapy ...
International audienceBackground: Daratumumab (Dara), an anti-CD38 monoclonal antibody, has an immun...
Purpose: Daratumumab treatment results in a marked reduction of CD38 expression on multiple myeloma ...
The use of proteasome inhibitors and immunomodulatory drugs in the clinical practice has contributed...
The efficacy of daratumumab depends partially on CD38 expression on multiple myeloma (MM) cells. We ...
Abstract Daratumumab is a human monoclonal antibody that targets CD38, a cell surface protein that i...