Antimalarial Terpenic Compounds Isolated from Plants Used in Traditional Medicine (2010–July 2016)

Malaria is an infectious tropical disease mainly affecting children and sub-Saharan Africa, being one of the major death causes with almost half of the world population at risk. Therefore and to face increasing parasite resistance to available treatments, there is an urgent need to discover new antimalarial drugs. Nature and mostly plants are a resourceful supplier of potential active metabolites, as shown by the successful example of the sesquiterpene lactone: artemisinin. Terpenoids are occurring widely in nature and display a lot of biological activities among which antiplasmodial effects. This review is a compilation of terpenic compounds isolated from plants with moderate (2 μ M < IC50 _ 11 μ M) to strong (IC50 _ 2 μ M) activity against different strains of Plasmodium published from 2010 to July 2016. Forty-seven references are identifi e