BACKGROUND Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) is highly lethal. In previous models of combined TBI + HS, we showed that early resuscitation with fresh frozen plasma (FFP) improves neurologic outcomes. Delivering FFP, however, in austere environments is difficult. Lyophilized plasma (LP) is a logistically superior alternative to FFP, but data are limited regarding its efficacy for treatment of TBI. We conducted this study to determine the safety and long-term outcomes of early treatment with LP in a large animal model of TBI + HS. METHODS Adult anesthetized swine underwent TBI and volume-controlled hemorrhage (40% blood volume) concurrently. After 2 hours of shock, animals were randomized (n = 5 per /group) to F...
Outcome after traumatic brain injury (TBI) is worsened by hemorrhagic shock (HS), but the optimal re...
Traumatic brain injury (TBI) is often accompanied by hemorrhage, and treatment of hemorrhagic shock ...
BACKGROUND Time to treatment matters in traumatic haemorrhage but the optimal prehospital use of ...
We have previously shown that early treatment with fresh frozen plasma (FFP) is neuroprotective in a...
Background: Optimal fluid resuscitation strategy following combined traumatic brain injury (TBI) and...
The original purpose of this study was to compare initial resuscitation of hemorrhagic hypotension a...
Background Hemorrhagic shock (HS) often causes coagulopathy due, in part, to decreased coagulation p...
The resuscitation of polytrauma with hemorrhagic shock and traumatic brain injury (TBI) is a balance...
Coagulopathy associated with traumatic brain injury (TBI) is recognized as one of the risk factors f...
In severe trauma and hemorrhage the early and empiric use of fresh frozen plasma (FFP) is associated...
Traumatic brain injury and hemorrhagic shock is associated with blood-brain barrier (BBB) breakdown ...
Background: Previously, we had shown that elevation of cerebral perfusion pressure, using pressors, ...
Objective: Traumatic brain injury (TBI) is one of the most common causes of morbidity and mortality....
Introduction: We have observed that early transfusion with shed blood vs saline improved cerebral pe...
Polynitroxylated-pegylated hemoglobin (PNPH), a bovine hemoglobin decorated with nitroxide and polye...
Outcome after traumatic brain injury (TBI) is worsened by hemorrhagic shock (HS), but the optimal re...
Traumatic brain injury (TBI) is often accompanied by hemorrhage, and treatment of hemorrhagic shock ...
BACKGROUND Time to treatment matters in traumatic haemorrhage but the optimal prehospital use of ...
We have previously shown that early treatment with fresh frozen plasma (FFP) is neuroprotective in a...
Background: Optimal fluid resuscitation strategy following combined traumatic brain injury (TBI) and...
The original purpose of this study was to compare initial resuscitation of hemorrhagic hypotension a...
Background Hemorrhagic shock (HS) often causes coagulopathy due, in part, to decreased coagulation p...
The resuscitation of polytrauma with hemorrhagic shock and traumatic brain injury (TBI) is a balance...
Coagulopathy associated with traumatic brain injury (TBI) is recognized as one of the risk factors f...
In severe trauma and hemorrhage the early and empiric use of fresh frozen plasma (FFP) is associated...
Traumatic brain injury and hemorrhagic shock is associated with blood-brain barrier (BBB) breakdown ...
Background: Previously, we had shown that elevation of cerebral perfusion pressure, using pressors, ...
Objective: Traumatic brain injury (TBI) is one of the most common causes of morbidity and mortality....
Introduction: We have observed that early transfusion with shed blood vs saline improved cerebral pe...
Polynitroxylated-pegylated hemoglobin (PNPH), a bovine hemoglobin decorated with nitroxide and polye...
Outcome after traumatic brain injury (TBI) is worsened by hemorrhagic shock (HS), but the optimal re...
Traumatic brain injury (TBI) is often accompanied by hemorrhage, and treatment of hemorrhagic shock ...
BACKGROUND Time to treatment matters in traumatic haemorrhage but the optimal prehospital use of ...