The role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in immune responses mediated by T-helper 2 (T2) lymphocytes is unknown. Here we characterize the development of allergic airway disease in TRAIL-deficient (Tnfsf10) mice and in mice exposed to short interfering RNA targeting TRAIL. We show that TRAIL is abundantly expressed in the airway epithelium of allergic mice and that inhibition of signaling impairs production of the chemokine CCL20 and homing of myeloid dendritic cells and T cells expressing CCR6 and CD4 to the airways. Attenuated homing limits T 2 cytokine release, inflammation, airway hyperreactivity and expression of the transcriptional activator STAT6. Activation of STAT6 by interleukin-13 restores airway...
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in tumour cells w...
The chemokines CCL21 and CCL19, and cell bound TNF family ligand lymphotoxin beta (LTβ), have been a...
The prevalence of asthma has markedly increased in recent decades. Asthma affects approximately ten ...
The role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in immune responses medi...
Allergic asthma is a complex disease characterized by acute inflammation of the airways that over ti...
Allergic asthma is a complex disease characterized by acute inflammation of the airways that over ti...
Chronic obstructive pulmonary disease (COPD) is a life-threatening inflammatory respiratory disorder...
The tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a widely expressed cytokine ...
Mouse models and in vitro cell culture were used to examine airway expression of the mucosal chemoki...
Mouse models and in vitro cell culture were used to examine airway expression of the mucosal chemoki...
© 2017 the American Physiological Society. The aim of this study is to elucidate the role of TRAIL d...
Background: Type 2 T helper lymphocytes (Th2 cells) and their cytokine products are important in the...
Ovalbumin (OVA)-sensitized BALB/c mice were i.n. instilled with recombinant TNF-related apoptosis in...
Ovalbumin (OVA)-sensitized BALB/c mice were i.n. instilled with recombinant TNF-related apoptosis in...
. These authors contributed equally to this work. Ovalbumin (OVA)-sensitized BALB/c mice were i.n. i...
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in tumour cells w...
The chemokines CCL21 and CCL19, and cell bound TNF family ligand lymphotoxin beta (LTβ), have been a...
The prevalence of asthma has markedly increased in recent decades. Asthma affects approximately ten ...
The role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in immune responses medi...
Allergic asthma is a complex disease characterized by acute inflammation of the airways that over ti...
Allergic asthma is a complex disease characterized by acute inflammation of the airways that over ti...
Chronic obstructive pulmonary disease (COPD) is a life-threatening inflammatory respiratory disorder...
The tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a widely expressed cytokine ...
Mouse models and in vitro cell culture were used to examine airway expression of the mucosal chemoki...
Mouse models and in vitro cell culture were used to examine airway expression of the mucosal chemoki...
© 2017 the American Physiological Society. The aim of this study is to elucidate the role of TRAIL d...
Background: Type 2 T helper lymphocytes (Th2 cells) and their cytokine products are important in the...
Ovalbumin (OVA)-sensitized BALB/c mice were i.n. instilled with recombinant TNF-related apoptosis in...
Ovalbumin (OVA)-sensitized BALB/c mice were i.n. instilled with recombinant TNF-related apoptosis in...
. These authors contributed equally to this work. Ovalbumin (OVA)-sensitized BALB/c mice were i.n. i...
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in tumour cells w...
The chemokines CCL21 and CCL19, and cell bound TNF family ligand lymphotoxin beta (LTβ), have been a...
The prevalence of asthma has markedly increased in recent decades. Asthma affects approximately ten ...