miR-30c is specifically repressed in patients with active pulmonary tuberculosis
- Spinelli, Silvana Virginia
- Fernández, Rocío del Valle
- Zoff, Luciana
- Bongiovanni, Bettina
- Díaz, Ariana
- D'attilio, Luciano David
- Santucci, Natalia Estefanía
- Alvarez, Tomás
- Marchesini, Marcela M.
- Bogue, Cristina
- Bay, Maria Luisa
- Bottasso, Oscar Adelmo
DOIAbstract
Tuberculous pleurisy (PLTB) is a common form of extrapulmonary tuberculosis. It often resolves without chemotherapy being hence considered a rather benign manifestation of the disease. Patients with PLTB mount an effective anti-mycobacterial response, unlike those with active pulmonary TB (pTB) that were shown to present an imbalance in plasma immune and endocrine mediators. In this work, we explored whether expression of the active isoform of the glucocorticoid receptor (hGRα) in the context of the inflammatory-anti-inflammatory responses of TB patients may be associated to microRNA levels. As expected, the inflammatory response triggered in patients coexists with increased circulating cortisol and altered hGRα levels in the peripheral blo...
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