Bone regeneration mediated by a bioactive and biodegradable extracellular matrix-like hydrogel based on elastin-like recombinamers
- Coletta, Dante Jesus
- Ibáñez Fonseca, Arturo
- Missana, Liliana Raquel
- Jammal, María Victoria
- Vitelli, Ezequiel J.
- Aimone, Mariangeles
- Zabalza, Facundo
- Issa, João P. Mardegan
- Alonso, Matilde
- Rodríguez Cabello, José Carlos
- Feldman, Sara
DOIAbstract
The morbidity of bone fractures and defects is steadily increasing due to changes in the age pyramid. As such, novel biomaterials that are able to promote the healing and regeneration of injured bones are needed to overcome the limitations of auto-, allo-, and xenografts, while providing a ready-To-use product that may help to minimize surgical invasiveness and duration. In this regard, recombinant biomaterials, such as elastin-like recombinamers (ELRs), are very promising as their design can be tailored by genetic engineering, thus allowing scalable production and batch-To-batch consistency, among others. Furthermore, they can self-Assemble into physically crosslinked hydrogels above a certain transition temperature, in this case body temp...
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