Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles
- Porta, Exequiel Oscar Jesús
- Jäger, Sebastián N.
- Nocito, Isabel
- Lepesheva, Galina I.
- Serra, Esteban Carlos
- Tekwani, Babu L.
- Labadie, Guillermo Roberto
DOIAbstract
A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as regioisomeric mixtures that were separated by column chromatography and then fully characterized. Most of the compounds displayed antiparasitic activity against Trypanosoma cruzi and Leishmania donovani. The most active compounds were assayed as potential TcCYP51 inhibitors.Fil: Porta, Exequiel Oscar Jesús. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil:...
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