Effect of seasonality on chemical composition and antibacterial and anticandida activities of Argentine propolis: Design of a topical formulation
- Isla, Maria Ines
- Dantur, Yanina
- Salas, Ana Lilia
- Danert, Fátima Carolina
- Zampini, Iris Catiana
- Arias, Myriam Elizabeth
- Ordóñez, Roxana Mabel
- Maldonado, Luis
- Bedascarrabure, Enrique
- Nieva Moreno, María Inés
DOIAbstract
The effect of seasonality on Argentine propolis collected during one year on its phenolic and flavonoid content and on the growth of Gram-positive and Gram negative antibiotic resistant bacteria and Candida species was evaluated. Extracts of propolis samples collected in the summer and spring showed higher phenolic and flavonoid contents than the samples collected in other seasons (5.86 to 6.06 mg GAE/mL and 3.77 to 4.23 mg QE/mL, respectively). The propolis collected in summer and autumn showed higher antibacterial activity (30 μg/mL) than the other samples (MIC values between 30 and 120 μg/mL). No antibacterial activity was detected against Gram-negative bacteria. Also, these extracts were able to inhibit the development of five Candida s...