Sphaerialactonam, a γ-lactam–isochromanone from the Hawaiian endophytic fungus Paraphaeosphaeria sp. FT462

Reinvestigation of the endophytic fungus Paraphaeosphaeria sp. FT462 from the Hawaiian plant Lycopodiella cernua (L.) Pic. Serm led to the isolation and identification of a unique γ-lactam-isochromanone (1). The structure of 1 was determined by NMR, MS spectroscopic analysis, and quantum chemical calculations of NMR. The compound was tested inactive against A2780 and A2780cisR.Fil: Huang, Peng. University Of Hawaii At Hilo; Estados Unidos. Anhui University of Chinese Medicine; ChinaFil: Li, Chunshun. University Of Hawaii At Hilo; Estados Unidos. University of Hawaii Cancer Center; Estados UnidosFil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Turkson, James. University of Hawaii Cancer Center; Estados UnidosFil: Cao, Shugeng. University Of Hawaii At Hilo; Estados Unidos. University of Hawaii Cancer Center; Estados Unido