Antibacterial activity and biocompability of zinc oxide and graphite particles as endodontic materials
- Kozuszko, Silvia Noemi
- Sanchez, Maria Alejandra
- de Ferro, María Inés Gutiérrez
- Sfer, Ana María
- Moreno Madrid, Ana Paula
- Takabatake, Kiyofumi
- Nakano, Keisuke
- Nagatsuka, Hitoshi
- Rodriguez, Andrea Paola
DOIAbstract
The aim of this work is to evaluate the antibacterial effect and biocompatibility of zinc oxide (ZnO) nanopaticles and graphite-type carbon (Gt) microparticles commercial powders. SEM analysis was performed to assess particles morphology. The antibacterial behavior was studied against Staphylococcus aureus (Staph. Aureus) (bacterial strain ATCC 29213) and TEM analysis of bacteria was performed to determine ultrastructural alterations; in addition, biocompatibility was evaluated in subcutaneous tissue of Wistar rats at 3, 7 and 28 d. ZnO and Gt powders exhibited antibacterial activity while TEM images of Staph. aureus showed membrane disruption followed by the release of internal content. Also, an electron-light region within the cytoplasm w...
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