Increased dietary levels of α-linoleic acid inhibit mammary tumor growth and metastasis
- Vara Messler, Marianela
- Pasqualini, María Eugenia
- Comba, Andrea
- Silva, Renata Alejandra
- Buccellati, Carola
- Trenti, Annalisa
- Trevisi, Lucia
- Eynard, Aldo Renato
- Sala, Angelo
- Bolego, Chiara
- Valentich, Mirta Ana
DOIAbstract
The aim of this study was to determine whether α-linolenic acid (ALA ω-3 fatty acid) enriched diet affects growth parameters when applied to a syngeneic model of mammary carcinoma. Materials and methods: BALB/c mice were divided and fed with: 1) a chia oil diet, rich in ALA or 2) a corn oil diet, rich in linoleic acid (LA ω-6 fatty acid). Mice were subcutaneously inoculated with a tumor cell line LM3, derived from a murine mammary adenocarcinoma. Results: After 35 days, tumor incidence, weight, volume and metastasis number were lower in the ALA-fed mice, while tumor latency time was higher, and the release of pro-tumor metabolites derived from ω-6 fatty acids decreased in the tumor. Compared to the control group, a lower number of mitosis, ...
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