An adverse immune-endocrine profile in patients with tuberculosis and type 2 diabetes

Fernández, Rocío del Valle
Díaz, Ariana
D'attilio, Luciano David
Bongiovanni, Bettina
Santucci, Natalia Estefanía
Bertola, D.
Besedovsky, H.
del Rey, A.
Bay, Maria Luisa
Bottasso, Oscar Adelmo

Open link

Publication date

December 2016

DOI

10.1016/j.tube.2016.09.001

Publisher

Elsevier BV

Journal

Tuberculosis

Abstract

Diabetes is a risk factor for the development of pulmonary tuberculosis (TB) and both diseases present endocrine alterations likely to play a role in certain immuno-endocrine-metabolic associated disorders. Patients with TB, or with TB and type 2 diabetes (TB + T2DM) and healthy controls (HCo) were assessed for plasma levels of cortisol, dehydroepiandrosterone (DHEA), estradiol, testosterone, growth hormone (GH), prolactin, insulin-like growth factor-1 (IGF-1), cytokines (IL-6, IL-10, IFN-γ) and the specific lymphoproliferative capacity of peripheral blood mononuclear cells. All patients had higher levels of cortisol with a reduction in DHEA, thus resulting in an increased cortisol/DHEA ratio (Cort/DHEA). Increased prolactin and particularl...