An unaware agenda: Interictal consciousness impairments in epileptic patients
- Moguilner, Sebastian Gabriel
- García, Adolfo Martín
- Mikulan, Ezequiel Pablo
- García, Maria del Carmen
- Vaucheret, Esteban
- Amarillo Gómez, Yimy
- Bekinchstein, Tristán
- Ibáñez Barassi, Agustín Mariano
DOIAbstract
Consciousness impairments have been described as a cornerstone of epilepsy. Generalized seizures are usually characterized by a complete loss of consciousness, while focal seizures have more variable degrees of responsiveness. In addition to these impairments that occur during ictal episodes, alterations of consciousness have also been repeatedly observed between seizures (i.e., during interictal periods). In this opinion paper, we review evidence supporting the novel hypothesis that epilepsy produces consciousness impairments which remain present interictally. Then, we discuss therapies aimed to reduce seizure frequency, which may modulate consciousness between epileptic seizures. We conclude with a consideration of relevant pathophysiolog...
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