Self-dispersible nanocrystals of albendazole produced by high pressure homogenization and spray-drying
- Paredes, Alejandro Javier
- Llabot, Juan Manuel
- Sanchez Bruni, Sergio Fabian
- Allemandi, Daniel Alberto
- Palma, Santiago Daniel
DOIAbstract
Albendazole (ABZ) is a broad-spectrum antiparasitic drug used in the treatment of human or animal infections. Although ABZ has shown a high efficacy for repeated doses in monogastric mammals, its low aqueous solubility leads to erratic bioavailability. The aim of this work was to optimize a procedure in order to obtain ABZ self-dispersible nanocrystals (SDNC) by combining high pressure homogenization (HPH) and spray-drying (SD). The material thus obtained was characterized and the variables affecting both the HPH and SD processes were studied. As expected, the homogenizing pressure and number of cycles influenced the final particle size, while the stabilizer concentration had a strong impact on SD output and redispersion of powders upon con...
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