Early postnatal exposure to endosulfan interferes with the normal development of the male rat mammary gland
- Altamirano, Gabriela Anahí
- Delconte, Melisa
- Gomez, Ayelen Luciana
- Alarcón, Ramiro
- Bosquiazzo, Veronica Lis
- Luque, Enrique Hugo
- Muñoz de Toro, Monica Milagros
- Kass, Laura
DOIAbstract
Our aim was to evaluate whether postnatal exposure to endosulfan (ENDO) modifies mammary gland (MG) development in pre- and post-pubertal male rats. From postnatal day 1 (PND1) to PND7, male rats were injected subcutaneously every 48 h with either corn oil (vehicle) or 600 μg ENDO/kg.bw. On PND21 and PND60, MG and blood samples were collected. Estradiol (E2) and testosterone (T) serum levels, MG histology, collagen fiber organization, proliferation index, and estrogen (ESR1) and androgen receptor (AR) expressions were evaluated. On PND21, E2 and T levels were similar between groups, whereas MG area, perimeter, number of terminal end buds and ESR1 expression were increased in ENDO-exposed rats. These changes were associated with alveolar dev...
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