Measurements of sublimation rate in a laboratory lyophilizer

V diplomski nalogi je obravnavana hitrost sublimacije pri liofilizaciji. Sublimacijsko sušenje je postopek, ki se veliko uporablja v farmaciji, saj pri tem načinu sušenja snov ne izgubi lastnosti, ki jih je imela na začetku. Postopek je izveden z neposrednim prehodom iz trdnega v plinasto agregatno stanje, za kar pa moramo zagotoviti ustrezne pogoje, da se izognemo trojni točki vode. Med izvajanjem meritev bomo spremljali temperaturo, za katero menimo, da vpliva na hitrost sublimacije, ter njen vpliv tudi preučili. Prav tako bomo hitrost določili tako, da bomo s snemanjem in obdelavo slik določali maso snovi v viali in rezultate preverili še s tehtanjem snovi med sušenjem.The diploma thesis researches the sublimation rate in liophylisation. Freeze-drying is a procedure widely used in pharmacy, because with this method the matter does not lose its original properties. The procedure is carried out with a direct transition from solid to gaseous state of matter. For that we need to ensure suitable conditions to avoid triple point of water. During the measurements we will observe the temperature, which should impact the speed of sublimation, and study its influence. To determine the speed we will determine the matter’s mass in a vial with recording and treatment of pictures. The results will also be examined with weighing the matter during the process of drying