The contribution of neuroinflammation and specifically brain lymphocyte invasion is increasingly recognised as a substantial pathophysiological mechanism after stroke. FTY720 is a potent treatment for primary neuroinflammatory diseases by inhibiting lymphocyte circulation and brain immigration. Previous studies using transient focal ischemia models showed a protective effect of FTY720 but did only partially characterize the involved pathways. We tested the neuroprotective properties of FTY720 in permanent and transient cortical ischemia and analyzed the underlying neuroimmunological mechanisms.FTY720 treatment resulted in substantial reduction of circulating lymphocytes while blood monocyte counts were significantly increased. The number of...
Injury due to brain ischemia followed by reperfusion (I/R) may be an important therapeutic target in...
Brain inflammation contributes to ischaemic and reperfusion injury, and thus worsens outcome after s...
<p><b>A,</b> Schematic diagram of the photothrombotic stroke model (left) and ischemic lesions evalu...
The contribution of neuroinflammation and specifically brain lymphocyte invasion is increasingly rec...
Background: FTY720, an immunomodulator derived from a fungal metabolite which reduces circulating ly...
Hypoxic-ischemic injury to the developing brain remains a major cause of significant long-term morbi...
Background: Evidence suggests that brain infiltration of lymphocytes contributes to acute neural inj...
Cerebral ischemia is accompanied by fulminant cellular and humoral inflammatory changes in the brain...
<p>(<b>A</b>) Brain sections were stained 5d after MCAO for T cells (CD3), B cells (B220), granulocy...
BackgroundFTY720 (fingolimod) is the first oral drug approved by the Food and Drug Administration fo...
<p>Hypoxic-ischemic injury to the developing brain remains a major cause of significant long-term mo...
AbstractInflammation is a pathological hallmark of traumatic brain injury (TBI). Recent evidence sug...
Stroke is a leading cause of mortality and disability worldwide. However, current treatment for stro...
Background: FTY720 (fingolimod, Gilenya (TM)) is an oral, blood-brain barrier (BBB)-passing drug app...
Injury due to brain ischemia followed by reperfusion (I/R) may be an important therapeutic target in...
Injury due to brain ischemia followed by reperfusion (I/R) may be an important therapeutic target in...
Brain inflammation contributes to ischaemic and reperfusion injury, and thus worsens outcome after s...
<p><b>A,</b> Schematic diagram of the photothrombotic stroke model (left) and ischemic lesions evalu...
The contribution of neuroinflammation and specifically brain lymphocyte invasion is increasingly rec...
Background: FTY720, an immunomodulator derived from a fungal metabolite which reduces circulating ly...
Hypoxic-ischemic injury to the developing brain remains a major cause of significant long-term morbi...
Background: Evidence suggests that brain infiltration of lymphocytes contributes to acute neural inj...
Cerebral ischemia is accompanied by fulminant cellular and humoral inflammatory changes in the brain...
<p>(<b>A</b>) Brain sections were stained 5d after MCAO for T cells (CD3), B cells (B220), granulocy...
BackgroundFTY720 (fingolimod) is the first oral drug approved by the Food and Drug Administration fo...
<p>Hypoxic-ischemic injury to the developing brain remains a major cause of significant long-term mo...
AbstractInflammation is a pathological hallmark of traumatic brain injury (TBI). Recent evidence sug...
Stroke is a leading cause of mortality and disability worldwide. However, current treatment for stro...
Background: FTY720 (fingolimod, Gilenya (TM)) is an oral, blood-brain barrier (BBB)-passing drug app...
Injury due to brain ischemia followed by reperfusion (I/R) may be an important therapeutic target in...
Injury due to brain ischemia followed by reperfusion (I/R) may be an important therapeutic target in...
Brain inflammation contributes to ischaemic and reperfusion injury, and thus worsens outcome after s...
<p><b>A,</b> Schematic diagram of the photothrombotic stroke model (left) and ischemic lesions evalu...