Variation in the FFAR1 Gene Modifies BMI, Body Composition and Beta-Cell Function in Overweight Subjects: An Exploratory Analysis
- Walker Celia G.
- Goff Louise
- Bluck Les J.
- Griffin Bruce A.
- Jebb Susan A.
- Lovegrove Julie A.
- Sanders Thomas A. B.
- Frost Gary S.
DOIAbstract
(rs2301151; rs16970264; rs1573611) on pancreatic function, BMI, body composition and plasma lipids. higher (P = 0.009) BMI and 1.53% higher (P = 0.002) body fat per C allele). Differences in plasma lipids were also associated with the BMI-increasing allele of rs2301151 including higher total cholesterol (0.2 mmol/L per G allele, P = 0.01) and with the variant A allele of rs16970264 associated with lower total (0.3 mmol/L, P = 0.02) and LDL (0.2 mmol/L, P<0.05) cholesterol, but also with lower HDL-cholesterol (0.09 mmol/L, P<0.05) although the difference was not apparent when controlling for multiple testing. There were no statistically significant effects of the three SNPs on insulin sensitivity or beta cell function. However accumulated r...
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