Changes in the thyroid status modify the metabolite pattern of air-breathing perch (Anabas testudineus) during monocrotophos (Nuvacran) exposure

Contains fulltext : 35028.pdf (publisher's version ) (Closed access)To address the thyroidal influence on the stress-related metabolic response in fish, we studied the metabolic pattern of airbreathing teleost, Anabas testudineus after exposing the fish to nuvacron, a monocrotophos pesticide (MCP). Significant changes in the levels of some diagnostically important metabolites and serum triiodothyronine (T3) and thyroxine (T4) were observed after MCP exposure in euthyroid, hyperthyroid and hypothyroid fish. Forty-eight hour exposure of perch to MCP while significantly increasing the levels of glucose, urea, triglycerides in the serum, total protein and RNA in the liver, and the activity of alkaline phosphatase and alanine aminotransferase in the serum and liver, reduced the concentration of liver glycogen and the activity of aspartate aminotransferase in theserum and liver. MCP exposure decreased the levels of serum T3 but not T4 levels. Analysis of the percentage of MCP toxicity on each parameter among the groups indicates that MCP had its maximum effect in the hyperthyroid fish when compared with stimulation by MCP was significantly less in hypothyroid perch. The data indicate that changes in the status of the thyroid modify the stressor-mediated metabolic changes in fish and hypothyroidism appears to be advantageous to fish during pesticideinduced stress