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Probiotics Prevent Intestinal Barrier Dysfunction in Acute Pancreatitis in Rats via Induction of Ileal Mucosal Glutathione Biosynthesis

  • Lutgendorff Femke
  • Nijmeijer Rian M.
  • Sandström Per A.
  • Trulsson Lena M.
  • Magnusson Karl-Eric
  • Timmerman Harro M.
  • van Minnen L. Paul
  • Rijkers Ger T.
  • Gooszen Hein G.
  • Akkermans Louis M. A.
  • Söderholm Johan D.
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Publication date
February 2009
Icon DOI
10.1371/journal.pone.0004512
Publisher
Public Library of Science

Abstract

During acute pancreatitis (AP), oxidative stress contributes to intestinal barrier failure. We studied actions of multispecies probiotics on barrier dysfunction and oxidative stress in experimental AP.<0.05) coinciding with an increase in mRNA expression of glutamate-cysteine-ligase catalytic (GCLc) and modifier (GCLm) subunits.Probiotic pre-treatment diminished AP-induced intestinal barrier dysfunction and prevented oxidative stress via mechanisms mainly involving mucosal glutathione biosynthesis

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