Retinoic Acid Signalling Is Activated in the Postischemic Heart and May Influence Remodelling
- Bilbija Dusan
- Haugen Fred
- Sagave Julia
- Baysa Anton
- Bastani Nasser
- Levy Finn Olav
- Sirsjö Allan
- Blomhoff Rune
- Valen Guro
DOIAbstract
All-trans retinoic acid (atRA), an active derivative of vitamin A, regulates cell differentiation, proliferation and cardiac morphogenesis via transcriptional activation of retinoic acid receptors (RARs) acting on retinoic acid response elements (RARE).We hypothesized that the retinoic acid (RA) signalling pathway is activated in myocardial ischemia and postischemic remodelling. (p = 0.02).The RA signalling pathway is activated in postischemic hearts and may play a role in regulation of damage and repair during remodelling
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