Significant Role of Estrogen and Progesterone Receptor Sequence Variants in Gallbladder Cancer Predisposition: A Multi-Analytical Strategy

) receptors in conferring risk of gallbladder cancer. (rs1042838) with GBC risk. Genotyping for all the polymorphisms was done using PCR-RFLP. Multifactor dimensionality reduction and classification and regression tree approaches were combined with logistic regression to discover high-order gene-gene interactions in hormonal pathway. -789 AA had the highest risk for GBC [OR = 3.9].-789 A>C variants in GBC susceptibility and the risk appears to be mediated through gallstone dependent pathway