Activation of p38MAPK Contributes to Expanded Polyglutamine-Induced Cytotoxicity
- Tsirigotis Maria
- Baldwin R. Mitchell
- Tang Matthew Y.
- Lorimer Ian A. J.
- Gray Douglas A.
DOIAbstract
The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood. model of neurodegeneration (spinocerebellar ataxia 1, or SCA-1).Taken together, our data implicate activated p38MAPK in disease progression and suggest that its inhibition may represent a rational strategy for therapeutic intervention in the polyglutamine disorders
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