The signaling pathways imposing hormonal control over adipocyte differentiation are poorly understood. While insulin and Akt signaling have been found previously to be essential for adipogenesis, the relative importance of their many downstream branches have not been defined. One direct substrate that is inhibited by Akt-mediated phosphorylation is the tuberous sclerosis complex 2 (TSC2) protein, which associates with TSC1 and acts as a critical negative regulator of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1). Loss of function of the TSC1-TSC2 complex results in constitutive mTORC1 signaling and, through mTORC1-dependent feedback mechanisms and loss of mTORC2 activity, leads to a concomitant block of Akt signaling to its ot...
Neurogenin3-driven deletion of tuberous sclerosis complex 1 (Tscl) activated mechanistic target of r...
Phosphorylation and activation of Akt1 is a crucial signaling event that promotes adipogenesis. Howe...
Growth factors, insulin signaling and nutrients are important regulators of β-cell mass and function...
The signaling pathways imposing hormonal control over adipocyte differentiation are poorly understoo...
BACKGROUND:The signaling pathways imposing hormonal control over adipocyte differentiation are poorl...
The kinase mammalian target of rapamycin (mTOR) exists in two multiprotein complexes (mTORC1 and mTO...
The kinase mammalian target of rapamycin (mTOR) exists in two multiprotein complexes (mTORC1 and mTO...
The kinase mammalian target of rapamycin (mTOR) exists in two multiprotein complexes (mTORC1 and mTO...
The kinase mammalian target of rapamycin (mTOR) exists in two multiprotein complexes (mTORC1 and mTO...
Here, we demonstrated that inhibition of mTOR with rapamycin has negative effects on adipocyte diffe...
International audienceMammalian target of rapamycin (mTOR), a highly conserved protein kinase that c...
International audienceMammalian target of rapamycin (mTOR), a highly conserved protein kinase that c...
International audienceMammalian target of rapamycin (mTOR), a highly conserved protein kinase that c...
Mammalian target of rapamycin (mTOR), a highly conserved protein kinase that controls cell growth an...
Insulin signaling in osteoblasts regulates global energy balance by stimulating the production of os...
Neurogenin3-driven deletion of tuberous sclerosis complex 1 (Tscl) activated mechanistic target of r...
Phosphorylation and activation of Akt1 is a crucial signaling event that promotes adipogenesis. Howe...
Growth factors, insulin signaling and nutrients are important regulators of β-cell mass and function...
The signaling pathways imposing hormonal control over adipocyte differentiation are poorly understoo...
BACKGROUND:The signaling pathways imposing hormonal control over adipocyte differentiation are poorl...
The kinase mammalian target of rapamycin (mTOR) exists in two multiprotein complexes (mTORC1 and mTO...
The kinase mammalian target of rapamycin (mTOR) exists in two multiprotein complexes (mTORC1 and mTO...
The kinase mammalian target of rapamycin (mTOR) exists in two multiprotein complexes (mTORC1 and mTO...
The kinase mammalian target of rapamycin (mTOR) exists in two multiprotein complexes (mTORC1 and mTO...
Here, we demonstrated that inhibition of mTOR with rapamycin has negative effects on adipocyte diffe...
International audienceMammalian target of rapamycin (mTOR), a highly conserved protein kinase that c...
International audienceMammalian target of rapamycin (mTOR), a highly conserved protein kinase that c...
International audienceMammalian target of rapamycin (mTOR), a highly conserved protein kinase that c...
Mammalian target of rapamycin (mTOR), a highly conserved protein kinase that controls cell growth an...
Insulin signaling in osteoblasts regulates global energy balance by stimulating the production of os...
Neurogenin3-driven deletion of tuberous sclerosis complex 1 (Tscl) activated mechanistic target of r...
Phosphorylation and activation of Akt1 is a crucial signaling event that promotes adipogenesis. Howe...
Growth factors, insulin signaling and nutrients are important regulators of β-cell mass and function...