Relationship between Interleukin-6 Gene Polymorphism and Hippocampal Volume in Antipsychotic-Naïve Schizophrenia: Evidence for Differential Susceptibility?

and hippocampal gray matter volume in antipsychotic-naïve schizophrenia patients in comparison with healthy controls. was genotyped using PCR and DNA sequencing. Psychotic symptoms were assessed using Scale for Assessment of Positive Symptoms and Scale for Assessment of Negative Symptoms. genotype interaction involving both right and left hippocampal volumes. Interestingly, this effect was significant only in men but not in women. in schizophrenia pathogenesis mediated through hippocampal volume deficit that is of possible neurodevelopmental origin