Conjugate Vaccine against Typhoid Fever: Randomized Clinical Testing in Healthy Adults
- van Damme Pierre
- Kafeja Froukje
- Anemona Alessandra
- Basile Venere
- Hilbert Anne Katrin
- De Coster Ilse
- Rondini Simona
- Micoli Francesca
- Qasim Khan Rana M.
- Marchetti Elisa
- Di Cioccio Vito
- Saul Allan
- Martin Laura B.
- Podda Audino
DOIAbstract
in European adults. (1·25 µg, 5·0 µg and 12·5 µg of Vi antigen) with the polysaccharide vaccine. formulations induced higher Vi antibody levels compared to licensed control, with clear dose response relationship. did not elicit safety concerns, was highly immunogenic and is therefore suitable for further clinical testing in endemic populations of South Asia
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