A Method for Generation Phage Cocktail with Great Therapeutic Potential
- Gu Jingmin
- Liu Xiaohe
- Li Yue
- Han Wenyu
- Lei Liancheng
- Yang Yongjun
- Zhao Honglei
- Gao Yu
- Song Jun
- Lu Rong
- Sun Changjiang
- Feng Xin
DOIAbstract
Bacteriophage could be an alternative to conventional antibiotic therapy against multidrug-resistant bacteria. However, the emergence of resistant variants after phage treatment limited its therapeutic application. pfu, significantly smaller (p<0.01) than that of single monophage. Moreover, a delayed administration of this phage cocktail was still effective in protection against K7 challenge.Our data showed that the phage cocktail was more effective in reducing bacterial mutation frequency and in the rescue of murine bacteremia than monophage suggesting that phage cocktail established by SBS method has great therapeutic potential for multidrug-resistant bacteria infection
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