Decreased Circulating C3 Levels and Mesangial C3 Deposition Predict Renal Outcome in Patients with IgA Nephropathy
- Kim Seung Jun
- Koo Hyang Mo
- Lim Beom Jin
- Oh Hyung Jung
- Yoo Dong Eun
- Shin Dong Ho
- Lee Mi Jung
- Doh Fa Mee
- Park Jung Tak
- Yoo Tae-Hyun
- Kang Shin-Wook
- Choi Kyu Hun
- Jeong Hyeon Joo
- Han Seung Hyeok
DOIAbstract
Mesangial C3 deposition is frequently observed in patients with IgA nephropathy (IgAN). However, the role of complement in the pathogenesis or progression of IgAN is uncertain. In this observational cohort study, we aimed to identify the clinical implications of circulating C3 levels and mesangial C3 deposition and to investigate their utility as predictors of renal outcomes in patients with IgAN.A total of 343 patients with biopsy-proven IgAN were enrolled between January 2000 and December 2008. Decreased serum C3 level (hypoC3) was defined as C3 <90 mg/dl. The study endpoint was end-stage renal disease (ESRD) and a doubling of the baseline serum creatinine (D-SCr).Of the patients, there were 66 patients (19.2%) with hypoC3. During a mean ...
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