Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis)
- Kager Liesbeth M.
- Schouten Marcel
- Wiersinga W. Joost
- de Boer J. Daan
- Lattenist Lionel C. W.
- Roelofs Joris J. T. H.
- Meijers Joost C. M.
- Levi Marcel
- Dondorp Arjen M.
- Esmon Charles T.
- van 't Veer Cornelis
- van der Poll Tom
DOIAbstract
, the causative agent of melioidosis, a common form of community-acquired Gram-negative (pneumo)sepsis in South-East Asia. infection as compared to WT mice, except for a difference in coagulation activation in plasma., while endogenous EPCR does not impact on the host response. These results add to a better understanding of the regulation of coagulation during severe (pneumo)sepsis
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