Decreased Bone Mineral Density in Adults Born with Very Low Birth Weight: A Cohort Study
- Hovi Petteri
- Andersson Sture
- Järvenpää Anna-Liisa
- Eriksson Johan G.
- Strang-Karlsson Sonja
- Kajantie Eero
- Mäkitie Outi
DOIAbstract
Very-low-birth-weight (VLBW, <1,500 g) infants have compromised bone mass accrual during childhood, but it is unclear whether this results in subnormal peak bone mass and increased risk of impaired skeletal health in adulthood. We hypothesized that VLBW is associated with reduced bone mineral density (BMD) in adulthood.The Helsinki Study of Very Low Birth Weight Adults is a multidisciplinary cohort study representative of all VLBW births within the larger Helsinki area from 1978 to 1985. This study evaluated skeletal health in 144 such participants (all born preterm, mean gestational age 29.3 wk, birth weight 1,127 g, birth weight Z score 1.3), and in 139 comparison participants born at term, matched for sex, age, and birth hospital. BMD wa...
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