Aromatase Gene Polymorphisms Are Associated with Survival among Patients with Cardiovascular Disease in a Sex-Specific Manner
- Beitelshees Amber L.
- Johnson Julie A.
- Hames Megan L.
- Gong Yan
- Cooper-DeHoff Rhonda M.
- Wu Jun
- Cresci Sharon
- Ma Cynthia X.
- Pepine Carl J.
- Province Michael A.
- Spertus John A.
- McLeod Howard L.
DOIAbstract
for its potential role in sex differences in cardiovascular disease outcomes. SNPs were genotyped (-81371 C>T, -45965 G>C, M201T, R264C, 80 A>G, and +32226 G>A). The sex*genotype interaction term was assessed for the primary outcome and compared by genotype in men and women when a significant interaction term was identified.We identified a significant interaction between -81371 C>T and sex (p = 0.025) in the ACS population. The variant allele was associated with a 78% increase in mortality in men (HR 1.78, 95% confidence interval [CI] 1.08-2.94) and a nonsignificant 42% decrease in mortality among women (HR 0.58, 95% CI 0.22-1.54). We identified a similar association in the hypertensive CAD group, the -81371 C>T*sex interaction term was p<...
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