The Dickkopf (DKK) family comprises a set of proteins that function as regulators of Wnt/β–catenin signaling and has a crucial role in development. Recent studies have revealed the involvement of this family in tumorigenesis, however their role in tumorigenesis is still remained unclear.We found increased expression of DKK2 but decreased expression of DKK1 in Ewing family tumor (EFT) cells. We showed that EFT-specific EWS/ETS fusion proteins enhance the DKK2 promoter activity, but not DKK1 promoter activity, via ets binding sites (EBSs) in the 5′ upstream region. EWS/ETS-mediated transactivation of the promoter was suppressed by the deletion and mutation of EBSs located upstream of the DKK2 gene. Interestingly, the inducible expression of E...
Enhanced stemness in colorectal cancer has been reported and it contributes to aggressive progressio...
EWS-FLI1 is a chimeric ETS transcription factor that is, due to a chromosomal rearrangement, specifi...
Dickkopf-1 (DKK1) is an inhibitor of the Wnt/β-catenin signaling pathway. However, the role of DKK1 ...
Background: The Dickkopf (DKK) family comprises a set of proteins that function as regulators of Wnt...
Background/Aims: Aberrant activation of the Wnt/β-catenin signaling pathway plays a key role in the ...
Aberrant activation of the Wnt signaling pathway is a major trait of many human cancers. Due to its ...
Ewing tumors (ET) are highly malignant, localized in bone or soft tissue, and are molecularly define...
Esophageal adenocarcinoma (EAC) is still associated with poor prognosis, despite modern multi-modal ...
© 2012 Dr. Pratiti BandopadhayayDesmoplastic small round cell tumor (DSRCT) is an aggressive tumor c...
Dickkopf-3 (Dkk-3) is a member of the Dickkopf family protein of secreted Wingless-related integrati...
Wnt signalling is a fundamental pathway involved in embryonic development and adult tissue homeostas...
Wnt signaling is an evolutionary highly conserved pathway that is modulated by several inhibitors an...
Dkk2 a antagonist of the Wnt/beta-catenin-signaling pathway was shown to be silenced in diverse canc...
EWS fusion oncoproteins underlie the pathogenesis of several human malignancies including Desmoplast...
Ewing’s sarcoma family of tumours (ESFT) are aggressive tumours with a tendency to metastasise, whic...
Enhanced stemness in colorectal cancer has been reported and it contributes to aggressive progressio...
EWS-FLI1 is a chimeric ETS transcription factor that is, due to a chromosomal rearrangement, specifi...
Dickkopf-1 (DKK1) is an inhibitor of the Wnt/β-catenin signaling pathway. However, the role of DKK1 ...
Background: The Dickkopf (DKK) family comprises a set of proteins that function as regulators of Wnt...
Background/Aims: Aberrant activation of the Wnt/β-catenin signaling pathway plays a key role in the ...
Aberrant activation of the Wnt signaling pathway is a major trait of many human cancers. Due to its ...
Ewing tumors (ET) are highly malignant, localized in bone or soft tissue, and are molecularly define...
Esophageal adenocarcinoma (EAC) is still associated with poor prognosis, despite modern multi-modal ...
© 2012 Dr. Pratiti BandopadhayayDesmoplastic small round cell tumor (DSRCT) is an aggressive tumor c...
Dickkopf-3 (Dkk-3) is a member of the Dickkopf family protein of secreted Wingless-related integrati...
Wnt signalling is a fundamental pathway involved in embryonic development and adult tissue homeostas...
Wnt signaling is an evolutionary highly conserved pathway that is modulated by several inhibitors an...
Dkk2 a antagonist of the Wnt/beta-catenin-signaling pathway was shown to be silenced in diverse canc...
EWS fusion oncoproteins underlie the pathogenesis of several human malignancies including Desmoplast...
Ewing’s sarcoma family of tumours (ESFT) are aggressive tumours with a tendency to metastasise, whic...
Enhanced stemness in colorectal cancer has been reported and it contributes to aggressive progressio...
EWS-FLI1 is a chimeric ETS transcription factor that is, due to a chromosomal rearrangement, specifi...
Dickkopf-1 (DKK1) is an inhibitor of the Wnt/β-catenin signaling pathway. However, the role of DKK1 ...