A Randomized Controlled Trial of Multicomponent Exercise in Older Adults with Mild Cognitive Impairment
- Suzuki Takao
- Shimada Hiroyuki
- Makizako Hyuma
- Doi Takehiko
- Yoshida Daisuke
- Ito Kengo
- Shimokata Hiroshi
- Washimi Yukihiko
- Endo Hidetoshi
- Kato Takashi
DOIAbstract
To examine the effect of multicomponent exercise program on memory function in older adults with mild cognitive impairment (MCI), and identify biomarkers associated with improvement of cognitive functions.<.05).The results suggested that an exercise intervention is beneficial for improving logical memory and maintaining general cognitive function and reducing whole brain cortical atrophy in older adults with amnestic MCI. Low total cholesterol and higher brain-derived neurotrophic factor may predict improvement of cognitive functions in older adults with MCI. Further studies are required to determine the positive effects of exercise on cognitive function in older adults with MCI.
Add to ORKG