Shift Towards Pro-inflammatory Intestinal Bacteria Aggravates Acute Murine Colitis via Toll-like Receptors 2 and 4
- Heimesaat Markus M.
- Fischer André
- Siegmund Britta
- Kupz Andreas
- Niebergall Julia
- Fuchs David
- Jahn Hannah-Katharina
- Freudenberg Marina
- Loddenkemper Christoph
- Batra Arvind
- Lehr Hans-Anton
- Liesenfeld Oliver
- Blaut Michael
- Göbel Ulf B.
- Schumann Ralf R.
- Bereswill Stefan
DOIAbstract
accumulates in murine ileitis and exacerbates small intestinal inflammation via Toll-like receptor (TLR) signaling.<0.01). Numbers of lactobacilli and clostridia remained unaffected by colitis, irrespective of the TLR-genotype of mice. Culture-independent molecular analyses confirmed the microflora shifts towards enterobacteria during colitis and showed that the gut flora composition was similar in both, healthy wt and TLR-deficient animals. may serve as a biomarker for colitis severity and DSS-induced barrier damage seems to be a valuable model to further identify bacterial factors involved in maintaining intestinal homeostasis and to test therapeutic interventions based upon anti-TLR strategies
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