Allogeneic Non-Adherent Bone Marrow Cells Facilitate Hematopoietic Recovery but Do Not Lead to Allogeneic Engraftment
- Fricke Stephan
- Ackermann Manuela
- Stolzing Alexandra
- Schimmelpfennig Christoph
- Hilger Nadja
- Jahns Jutta
- Hildebrandt Guido
- Emmrich Frank
- Ruschpler Peter
- Pösel Claudia
- Kamprad Manja
- Sack Ulrich
DOIAbstract
mice. donor chimerism of 5.8±2.4% [day 40], P<.001). Allogeneic NA-BMCs preserved 62.5% (n = 8) of mice from death without detectable hematopoietic donor chimerism. Transplantation of syngeneic bone marrow cells preserved 100%, transplantation of allogeneic bone marrow cells 33% of mice from death.NA-BMCs triggered endogenous hematopoiesis and induced faster recovery compared to bone marrow controls. These findings may be of relevance in the refinement of strategies in the treatment of hematological malignancies
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